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Sonic Maximizer
BBE 882i Sonic Maximizer: Excitement Of Sound Enhancement
Tablet Dissolution for Content Uniformity Testing and HPLC Assay
Ultrasonic energy, applied in a process called sonication, is widely used to dissolve pharmaceutical tablets for HPLC assay procedures such as content uniformity testing. The sonicator kits can also be used to mix and disperse samples, and for solvent degassing. Sonicator kits are ideal for USP methods that specify the use of an ultrasonic cleaning for sample preparation. Many methods detailed by the USP recommend using an ultrasonic bath to extract the active pharmaceutical ingredient (API) from tablet formulations.
When preparing pharmaceutical samples for HPLC assay care must be taken to avoid chemical degradation of the API due to excessive heat. For this reason it is important that sonication is accomplished quickly as the process itself generates heat. One way to achieve this goal is to use a pharmaceutical tablet sonicator kit, the components of which enable the completion of tablet dissolution up to 16 times faster than conventional systems. Rapid tablet dissolution and excellent active pharmaceutical ingredient recovery is further supported because the ultrasonic bath design eliminates sonication dead spots and maximizes the ultrasonic power, with operation at 320 and 415 watts respectively for the two models. The combined features of these units minimize heat buildup, increase ultrasonic power dispersion, and minimize transducer burn marks and flask etching.
These tabletop tablet sonication kits include specially designed racks to position sample flasks at just the right depth in an ultrasonic bath to allow maximum acoustic energy to reach the flasks. The bath consists of water and an optional sonic amplifier additive to enhance cavitation.
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About iUltrasonic
iUltrasonic The expert iUltrasonic.com staff understands the technical needs of professionals in every industry and the importance of the right equipment and reliable suppliers. Ultrasonic cleaners are selected for performance and value from a range of high quality manufacturers.
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64 Twin Oaks Oval Springfield,
NJ 07081
973 821-4400
www.iultrasonic.com
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